International Symposium on Protein Interactions and Self-assembly


14-16 July, Lisboa, Portugal

Welcome

The International Symposium on Protein Interactions and Self-assembly will be held in the beautiful city of Lisboa, Portugal, from 14th to 16th July 2025. The meeting will include a strong scientific program consisting of experts in the protein folding and conformational diseases field, as well as on protein-based technologies. A broad spectrum of topics will be covered during this meeting, including biophysics of protein aggregates, molecular mechanisms of protein-protein interactions, approaches for targeting protein misfolding and aggregation, and functional protein-based biomaterials and therapeutics.

The program will also include oral and poster presentations selected from submitted abstracts.

We cordially invite you to attend the International Symposium on Protein Interactions and Self-assembly and contribute for shaping the future of this field!


Cláudio M. Gomes
Meeting Chair 

Program Abstract Call
Caleidoscopio

Speakers

CGomes

Cláudio M. Gomes

Ciências ULisboa
Portugal

KLindorff-Larsen

Kresten Lindorff-Larsen

University of Copenhagen
Denmark

EGazit

Ehud Gazit

University of Tel Aviv
Israel

MVendrusculo

Michele Vendruscolo

University of Cambridge 
United Kingdom

JKumita

Janet Kumita

University of Cambridge 
United Kingdom

FHerrera

Federico Herrera

Ciências ULisboa
Portugal

MBarile

Maria Barile

University of Bari Aldo Moro
Italy

RSantos

Romana Santos

Ciências ULisboa
Portugal

MMachuqueiro
Miguel Machuqueiro

Ciências ULisboa
Portugal

MMachuqueiro
Jihane Basbous

CNRS
France

BHenriques
Bárbara Henriques

Ciências ULisboa
Portugal

AMelo
Ana M. Melo

IST ULisboa / iBB
Portugal

SJackson
Sophie Jackson

University of Cambridge
United Kingdom

JMano
João Mano

CICECO – Aveiro Institute of Materials
Portugal

TBandeiras
Tiago Bandeiras

Merck Healthcare Lab / iBET
Portugal

HHeise
Henrike Heise

Heinrich Heine University Düsseldorf
Germany

MCastanho
Miguel Castanho

Gulbenkian Institute for Molecular Medicine
Portugal

GSkretas
Georgios Skretas

National Hellenic Research Foundation
Greece

ZDosztanyi
Zsuzsanna Dosztanyi

Eötvös Loránd University
Hungary 

PRLino
Paulo Roque Lino

Hovione - R&D Development
Portugal

Program Details

13:15 – 14:00  Meeting registration

14:00 – 14:10   Welcome & Opening 

14:10 – 14:40   Ehud Gazit: Peptide and metabolite self-assembly

14:40 – 14:55   Selected oral presentation: Amyloid forming human lysozyme intermediates are stabilised by non-native amide-𝝅 interactions, Minkoo Ahn (University of Bristol)

14:55 – 15:15   Romana Santos: Nature inspired protein-based bioadhesion

15:15 – 15:45   João Mano: Protein-based biomaterials

15:45 – 16:10   Coffee break

16:10 – 16:40   Maria Barile: Cofactor metabolism and protein interactions in pathology

16:40 – 17:00   Bárbara J. Henriques: Protein misfolding in metabolic diseases

17:00 – 17:15   Selected oral presentation: Classification of tauopathies from human brain homogenates through salt-modulated Tau amplification, Alessia Santambrogio (University of Cambridge)

17:15 – 17:45   Sophie Jackson: Self-assembly of therapeutic peptides

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18:30   Networking moment

09:30 – 10:00   Kresten Lindorff-Larsen: Prediction and analysis of condensates of disordered proteins

10:00 – 10:30   Ana M. Melo: Untangling the membrane binding of disordered proteins involved in neurodegeneration 

10:30 – 10:45   Selected oral presentation: ​​When neighbours play a role: a systems-level analysis of protein  interactions conditioning cancer driver mutation effects, Francisco Rodrigues Pinto (Ciências ULisboa/BioISI)

10:45 – 11:25   Janet Kumita: Developing tuneable synthetic biomolecular condensates as a targeted protein  degradation for neurodegenerative diseases

11:25 – 11:55   Coffee break

11:55 – 12:15   Miguel Machuqueiro: A computational method to capture pH effects at the biomolecular interfaces

12:15 – 12:30   Selected oral presentation: Selective interactions and synergistic pathology: Alpha-synuclein’s  role in modulating Aβ aggregation and protein networks in disease, André Leitão (University of Zurich)

12:30 – 13:00   Jihane Basbous: Biomolecular condensates in DNA repair: Why composition matters

13:00 – 14:30   Lunch

14:30 – 15:00   Georgios Skretas: A bacterial discovery platform for small cyclic peptides that effectively rescue the misfolding and aggregation of proteins associated with human diseases

15:00 – 15:30   Zsuzsanna Dosztanyi: Expanding roles of LC8 in protein self-assembly and centrosomal architecture

15:30 – 16:00   Cláudio M. Gomes: Proteostasis beyond cell boundaries in misfolding diseases

16:00 – 16:30   Coffee break

16:30 – 17:00   Poster pitch

17:00 – 18:30   Poster session

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20:00   Meeting dinner 

09:30 – 10:00   Michele Vendruscolo: Drug discovery to target protein misfolding and aggregation

10:00 – 10:15   Selected oral presentation: Interactions of SLC3A2 with members of the SLC7 transporter family: role in membrane trafficking, Cesare Indiveri (CNR - IBIOM/University of Calabria)

10:15 – 10:35   Federico Herrera: Alterations in the subcellular distribution of self-associating and aggregation-prone proteins in the context of spastic ataxias

10:35 – 11:05   Paulo Roque Lino: Dispersome®: A protein-based excipient enabling high-efficiency pulmonary drug delivery

11:05 – 11:35   Coffee break

11:35 – 12:05   Henrike Heise: Protein unfolding and aggregation at all stages as seen by NMR

12:05 – 12:35   Tiago Bandeiras: Extract2Chip - Bypassing protein purification in drug discovery

12:35 – 12:50   Selected oral presentation: Dynamic ensembles of SARS-CoV-2 N-protein reveal head-to-head coiled-coil-driven oligomerization and phase separation, Tiago Cordeiro (Universidade Nova de Lisboa/ITQB NOVA)

12:50 – 13:20   Miguel Castanho: Tackling the urgent need for a broad-spectrum antiviral drug: from self-assembly of peptides to in vivo action

13:20 – 13:30  Closing remarks

13:30   Lunch

Important Information

Abstracts Submission Deadline

30 June

Registration Fee

Waived for all selected participants

Registration includes:
    - Coffee breaks and lunches
    - Networking moment (Monday, 14 July)
    - Meeting dinner (Tuesday, 15 July)

• The event will have a limited number of participants, who will be selected based on the scientific merit of the submitted abstracts
• Selection announcement (by email notification) until 2 July
 
______________________________

Abstract call for Oral and Poster Presentations

As part of the meeting's scientific program, participants will have the opportunity to present their work through Oral Communications and Poster Communications, fostering knowledge exchange and collaboration across the scientific community. Sharing science will be at the centre of this symposium and we are much looking forward to all participant's contributions.

• Submission deadline: 30 June

Abstract submission

Venue & Contact

Address

Campo Grande 18, 1700-162 Lisboa
(GPS: 38.757030, -9.153601)

Email

twin2pipsa@ciencias.ulisboa.pt

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Faculdade de Ciências, Universidade de Lisboa
FCiências.ID - Associação para a Investigação e Desenvolvimento de Ciências
Campo Grande 1749-016 Lisboa Portugal

Funded by the EU (TWIN2PIPSA, GA 101079147). Views and opinions expressed are however those of the authors only and do not necessarily reflect those of the EU or European Research Executive Agency (REA). Neither the EU nor the granting authority can be held responsible for them.

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