TWIN2PIPSA

Twinning for Excellence in Biophysics of
Protein Interactions & Self-Assembly

An EU-funded project coordinated by FC.ID/ULisboa
Faculdade de Ciências Universidade de Lisboa

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Meet the team

A group of 11 scientists from Ciências/ULisboa together with our partners from Tel Aviv University (TAU), University of Copenhagen (UCPH), and the University of Cambridge (UCAM), make up the team of experts that collaborate under the TWIN2PIPSA project.

Consortium >
3D_Molecule
Twinning for Excellence in Protein Science

Learn about TWIN2PIPSA's main goal to establish FC.ID/ULisboa as a reference in the field of protein folding biophysics and conformational diseases, promoting impactful research on protein folding in diseases and bioadhesives.

About TWIN2PIPSA >
Lab_material
What do we aim for?

TWIN2PIPSA strives to promote cutting-edge research on protein science by facilitating networking between scientists and teams, training opportunities, communication, and connections with industry to achieve innovation in biomedicine and biotechnology.

Activities >

What has been happening?

Publications, seminars, events and more
TWIN2PIPSA_EstudoEmCasa2
Apr 18, 2024
 Seminar: In silico methods to capture the pH effects in drug binding to proteins and membranes

Miguel Machuqueiro, the head of the Computational BiopHysics Lab at BioISI and member of the TWIN2PIPSA Ciências ULisboa team, is going to present the most recent research results of his team at the upcoming BioISI Research Seminar. Don't lose this chance to learn and discuss state-of-the-art science with the TWIN2PIPSA researchers.

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TWIN2PIPSA_3DBioInfoPT_Workshop
Apr 12, 2024
 3D-BioInfo-PT Advanced Workshop

Take this opportunity to expand your knowledge on Computational Structural Biology tools with this free workshop promoted by the 3D-BioInfo-PT community and TWIN2PIPSA researchers.
Registration is mandatory and is open until April 5th (register here).

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TWIN2PIPSA_EstudoEmCasa2
Apr 9, 2024
 Webinar for Middle- and High-school Students on 'Marine Molecules in Our Daily Lives'

Promoted by Escola Azul under the scope of the project #EstudoEmCasa@ of the Learning Recovery Plan of the Portuguese Government, Prof. Romana Santos from Ciências ULisboa hosted a webinar (in Portuguese) in which she showcased several types of molecules that can be extracted from marine organisms and can be applied in everyday products, including foods, cosmetics, medicines, and detergents.

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TWIN2PIPSA_DNE4
Apr 5, 2024
 Meeting: 20th International Symposium of the Portuguese Society of Metabolic Disorders

Bárbara J. Henriques was invited to present at the 20th International Symposium of the Portuguese Society of Metabolic Disorders, held in Aveiro, Portugal. Dr. Henriques presented her most recent research findings on the biochemical pathological processes underlying the development of multiple acyl-CoA dehydrogenase deficiency (MADD).

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TWIN2PIPSA_DNE4
Mar 25, 2024
 Digital Networking Event: Piezoelectric Biomaterials Toward Energy Harvesting

Post-doctoral researcher Hui Yuan, from Ehud Gazit's lab at University of Tel Aviv, presented their more recent findings that expand the knowledge on the use of amino acids and short peptides as sources of energy that may exploited for the development of wearable and implantable electrical devices.

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TWIN2PIPSA_Biotech_Event
Mar 05-09, 2024
 Congress: AD/PD 2024

Prof. Cláudio Gomes and four PhD students supervised by him, as well as the PhD students Alicia González Díaz and Alexander Röntgen from UCAM, presented
their most recent research findings at the ADPD/2024 Alzheimer's & Parkinson's Diseases Conference, in Lisbon, Portugal.

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TWIN2PIPSA_Biotech_Event
Feb 20, 2024
 Event: Bridging opportunities and forging partnerships with biotech/industrial stakeholders 

The TWIN2PIPSA team along with Tec Labs, the Innovation Center of Ciências ULisboa, hosted an event aiming to cultivate synergies and forge strategic partnerships with biotech and industrial stakeholders, focusing on advancements in protein-based technologies, biologics, and products. During this event the participants had the opportunity to know more about the infrastructures and technology available in the TWIN2PIPSA laboratories and discover National and International companies with synergistic interest.

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TWIN2PIPSA_IDWGS
Feb 16, 2024
Seminar: Physics of Knotter Proteins

Patrícia Faísca gave a talk on the mysteries of knotted proteins to college students during the Portuguese National Meeting of Physics Students (ENEF) that was held 5-18 Feb. at Ciências ULisboa. Aiming to provide a new perspective on physics and its teaching, the TWIN2PIPSA researcher provided an overview of the intricated biophysical features of knotted proteins and their relevance in biology.

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TWIN2PIPSA_IDWGS
Feb 11, 2024
Paper: Secondary Modification of S100B Influences Anti Amyloid-β Aggregation Activity and Alzheimer’s Disease Pathology

Led by Cláudio Gomes, ULisboa researchers and collaborators published a study in the International Journal of Molecular Sciences that sheds light on the role of S100B pro-inflammatory protein in the regulation of amyloid-β aggregation and the progression of Alzheimer's disease.

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TWIN2PIPSA_IDWGS
Feb 11, 2024
International Day of Women and Girls in Science 

In this day, the scientific community  celebrates all the women and girls who devote their lives to advance the scientific and technological knowledge. The TWIN2PIPSA embraces this important day by acknowledging all the women that take part of this project and contribute for the future of protein self-assembly and folding research.

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TWIN2PIPSA_CRISPR_Workshop
Feb 7, 2024
Workshop: How to design a CRISPR/Cas9 system to study protein-protein interactions in live cells 

Hosted by Prof. Federico Herrera from Ciências ULisboa and lectured by Alicia González Díaz from University of Cambridge, this online workshop covered the fundamentals of CRISPR/Cas9 technology. The participants had the opportunity to have a detailed overview of CRISPR/Cas9-based tools that can be applied to explore and uncover protein-protein interactions.

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TWIN2PIPSA_RSantos_#EstudoEmCasa
Jan 23, 2024
Webinar for Middle- and High-school Students on the Innovative Potential of Materials Inspired in Marine Organisms 

Promoted by Escola Azul under the scope of the project #EstudoEmCasa@ of the Learning Recovery Plan of the Portuguese Government,  Prof. Romana Santos from Ciências ULisboa gave a webinar (in Portuguese) in which she showcased several innovative products inspired in marine organisms and explore the importance of biomimicry for the resolution of the current societal challenges and the growth of the Blue Economy.

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TWIN2PIPSA_RSantos_InnovationContest
Jan 18, 2024
Ciências ULisboa | Tec Labs Internal Competition for Science Innovation Projects 

The innovation project SUNECTIN led by Prof. Romana Santos was shortlisted for the final selection step in the Competition for Science Innovation Projects promoted by Ciências ULisboa and Tec Labs. The selected projects were competing for a 50.000€ grant to support the development of their innovation ideas and leverage their transition into the biotech ecosystem.

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TWIN2PIPSA_FCID_UCAM_Exchange
Jan 15-16, 2024
Science Management Staff Exchange to University of Cambridge

Bárbara Matos, from the Pre-Award Department, and Carla Marques, the head of the Post-award department at FCiências.ID, have traveled to the UK to learn science management strategies and acquire new skill with their peers at the University of Cambridge (UCAM). 

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TWIN2PIPSA_Sandra
Jan 15-17, 2024
Training School 2: From pathological protein aggregation to drug discovery

The ULisboa team traveled to Cambridge (UK) to learn from UCAM researchers on advanced experimental techniques to assess pathological protein aggregates and how such information can be applied for the development of therapeutic and diagnostic tools.

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TWIN2PIPSA_Sandra
Jan 9, 2024
Visit of High School Students to Ciências ULisboa

Students from the Escola Secundária de Cascais visited the Ciências ULisboa, including several TWIN2PIPSA research laboratories. The students had the opportunity to learn more about the computational and experimental methodologies used by the teams of Federico Herrera, Miguel Machuqueiro, Paulo Costa, Cláudio Gomes, and Bárbara Henriques to explore the features of normal, mutated, and misfolded proteins in human health and disease.

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TWIN2PIPSA_Sandra
Dec 14, 2023
Expert Seminar: Targeting Ataxin-3 aggregation: Clues for Machado-Joseph's disease therapy

Prof. Sandra Macedo-Ribeiro, PhD, from the Instituto de Investigação e Inovação em Saúde da Universidade do Porto shared with the Ciências ULisboa community 20 years of research expertise on the role of amyloids in Machado Joseph's disease. An example off scientific perseverance for improving the lives of those affected by this rare disease.

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TWIN2PIPSA_OnsiteTraining
Dec 11-13, 2023
On-Site Training: Computational strategies for analysing protein structures 

Francesco Pesce, PhD, and Matteo Cagiada, PhD, from the University of Copenhagen have came to Ciências ULisboa to explore with the TWIN2PIPSA members different computational tools that can be used to assess the structures of disordered proteins and the impact of genetic mutations.

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TWIN2PIPSA_YorgosSkretas
Dec 6, 2023
Expert Seminar: Bacteria to the rescue: engineering microorganisms to function as an early-stage living drug discovery platform for protein misfolding diseases

Prof. Georgios Skretas, PhD, from the Alexander Fleming Biomedical Sciences Research Center, and a collaborator of Prof. Cláudio Gomes (ULisboa), presented a new screening platform based on bacteria that can be used to explore strategies to target disease-related aggregation-prone proteins.

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TWIN2PIPSA_Interview_Antena_2
Dec 6, 2023
Workshop: Navigating EU Research & Innovation Funding: Leveraging Current Experiences for Future Opportunities

Promoted by TWIN2PIPSA, this workshop provided a strategic vision on consortium participation in key EU funding program calls to the FCiências.ID/ULisboa and CIÊNCIAS ULisboa community.

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TWIN2PIPSA_Interview_Antena_2
Nov 27, 2023
Interview: TWIN2PIPSA project in Antena 2 Ciência (in portuguese)

The TWIN2PIPSA project was in the spotlight of Antena 2 Ciência podcast/radio program in an interview to Professor Cláudio Gomes, who explained the main features and importance of misfolded proteins and the potential societal impact of this twinning project. Listen to the interview here.

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TWIN2PIPSA_TS1_UCPH
Nov 13-16, 2023
Training School 1: Integrating experimental and computational approaches in protein self-assembly

The ULisboa team traveled to Copenhagen (Denmark) to learn from UCPH  researchers about advanced experimental and computational techniques used for the study of proteins and their interactions, as well as their relationships to function and disease.

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Ciencias R&I day 2023
Oct 24, 2023
Event: Ciências Research and Innovation Day 2023

Professor Cláudio Gomes and the PhD students Nuno Oliveira, Margarida Simões, Fernanda Murtinheira, and Inês Ventura presented the most recent findings of the TWIN2PIPSA ULisboa team at the 5th edition of Ciências Research & Innovation Day, an event that aims to showcase the best science made in Faculdade de Ciências da Universidade de Lisboa.

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Faidon Brotzakis paper
Oct 23, 2023
Digital Networking Event: AlphaFold Prediction of Structural Ensembles of Disordered Proteins. Faidon Brotzakis (UCAM)

Post-doctoral researcher Faidon Brotzakis, from Michele Vendruscolo's lab at University of Cambridge, presented their more recent findings that expand our knowledge on the use of deep learning methods to predict the structure of disordered proteins.

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UCAM Exchange MMachuqueir & SFerreira
Oct 16-20, 2023
Scientific Exchanges to University of Cambridge

PhD student Sara Ferreira and principal investigator Miguel Machuqueiro went on a Scientific Exchange to the University of Cambridge (UCAM), in UK, in which they had the opportunity to engage in enriching scientific discussions with Profs. Sophie Jackson, Michele Vendruscolo, Jenny Zhang, Paul Barker, and Sir Alan Fersht from the Yusuf Hamied Department of Chemistry.

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AFigueira @ EMBO|FEBS course 2023
Oct 3-6, 2023
Seminar: The regulation of Aβ42 oligomerization and aggregation by multimers of the S100B chaperone. António J. Figueira (BioISI)

PhD student António J. Figueira, from the Protein Misfolding and Amyloids in Biomedicine Lab (BioISI), attended the
prestigious EMBO|FEBS Susan Lindquist School on Proteostasis that was held in Ingelheim am Rhein (Germany), where he shared his work with top experts on the field.

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NEI2023
Sep 29, 2023
Event: European Researchers' Night - Lisboa

TWIN2PIPSA was at the 2023 European Researchers' Night in Lisbon. Visitants could talk with Prof. Romana Santos, PhD and her team about marine-inspired biomaterials; learn about computational modelling of biomolecules with Miguel Machuqueiro, PhD and Paulo Costa, PhD; and discover how human cells behave in disease with Prof. Federico Herrera, PhD.

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IVentura PhD review
Sep 29, 2023
PhD Review: New underwater sea urchin inspired bioadhesives. Inês Ventura (BioISI/MARE).

PhD student Inês Ventura discussed her most recent work on bio-inspired adhesives with Birgit Lengerer, PhD (University of Innsbruck), top expert in the field of biological adhesion. The open session was also attended by her supervisors Prof. Romana Santos, PhD (FCUL/MARE) Bárbara J. Henriques, PhD (FCUL/BioISI) and and Patrick Flammang, PhD (University of Mons). Great job Inês!

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Ayala Lampel
Sep 18-19, 2023
Expert Seminar: Designer biomolecular condensates formed by peptide liquid-liquid phase separation. Ayala Lampel (TAU).

Prof. Ayala Lampel, PhD, from Tel Aviv University (TAU), visited ULisboa to get to know TWIN2PIPSA's Lisbon-based research groups. She also shared her team's latest work on synthetic biomolecular condensates with a seminar, and engaged in exciting discussions for future collaborations.

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Sep 13, 2023
Expert Seminar: Interactions and conformational switching of Bcl-2 protein family of apoptotic regulators. Alexey Ladokhin (KU)

Prof. Alexey Ladokhin, PhD, from the University of Kansas Medical Center, collaborator of PI Miguel Machuqueiro, PhD (BioISI), visited FCUL (ULisboa) to present his group's recent research on membrane-induced conformational switching in Bcl-2 proteins and their role in the regulation of apoptosis. 

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Sep 05-07, 2023
Conference: 5th International Symposium on Pathomechanisms of Amyloid Diseases

PhD student António J. Figueira and TWIN2PIPSA Coordinator Prof. Cláudio M. Gomes, PhD, from the Protein Misfolding and Amyloids in Biomedicine Lab (BioISI), attended the 5th International Symposium on Pathomechanisms of Amyloid Diseases in Bordeaux, France; where they talked about their most recent work on S100 chaperones and their role in the regulation of protein aggregation in Alzheimer's Disease.

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Sep 01-08, 2023
Seminar: Anti-S100B nanobodies as modulators of Tau aggregation. Margarida Simões (BioISI).

PhD student Margarida Simões, from the Protein Misfolding and Amyloids in Biomedicine Lab (BioISI), participated in the FEBS Advanced Course on Protein Folding, Aggregation and Compartimentalization at Spetses Island, Greece. There, she was able to meet with top experts on the field while also sharing her current research on anti-S100B nanobodies with a talk, pitch and poster.

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Jul 31 - Aug 04, 2023
Congress: EBSA 2023

PhD student Joana Ribeiro, together with PIs Bárbara J. Henriques, PhD and Prof. Cláudio M. Gomes, PhD, from the Protein Misfolding and Amyloids in Biomedicine Lab (BioISI) attended the European Biophysical Societies' Association (EBSA) 2023 Congress in Stockholm, Sweden. There, with a talk and posters, they showcased their team's recent work on protein biophysics for rare metabolic disorders.

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FHerrera @ TAU
Jul 19, 2023
Seminar: Monitoring protein dynamics in living cells in the context of neurodegenerative disorders. Federico Herrera (BioISI)

Prof. Federico Herrera, PhD, PI from the Cell Structure and Dynamics Lab (BioISI), who is also TWIN2PIPSA's Grant Office Capacity Building Liaison Person, shared his group's recent work on cell models for studying protein aggregation with a seminar during his Scientific Exchange to Tel Aviv University.

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BHenriques @ Tau
Jul 19, 2023
Seminar: Acyl-CoA metabolites as a regulators of enzyme function through protein acylation. Bárbara J. Henriques (BioISI)

TWIN2PIPSA Dissemination and Communication Manager and PI Bárbara J. Henriques, PhD gave a seminar during her Scientific Exchange to Tel Aviv University, where she shared her team's latest work on rare metabolic disorders.

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RSantos @ TAU
Jul 19, 2023
Seminar: Sea urchin inspired adhesives for biotechnological and biomedical applications. Romana Santos (MARE)

TWIN2PIPSA Local Innovation Executive and PI Prof. Romana Santos, PhD, from the Bioadhesion & Biomimicry group at MARE (MARE) gave a seminar on bio-inspired adhesives as part of her Scientific Exchange to Tel Aviv University.

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CGomes @ TAU
Jul 19, 2023
Seminar: Novel chaperones counteracting protein aggregation in neurodegeneration. Cláudio M. Gomes (BioISI)

As part of their exchange to Tel Aviv University, TWIN2PIPSA Coordinator Prof. Cláudio M. Gomes, PhD, showed his team's latest work with a seminar on anti-aggregation chaperones in neurodegeneration.

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ULisboa @ TAU July
Jul 18-23, 2023
Scientific Exchanges to Tel Aviv University. Cláudio M. Gomes, Romana Santos, M Bárbara J. Henriques, Federico Herrera

TWIN2PIPSA Coordinator Prof. Cláudio M. Gomes, PhD, and PIs Prof. Romana Santos, PhD, Bárbara J. Henriques, PhD and Prof.  Federico Herrera, PhD, visited Tel Aviv University (TAU) in Israel, meeting with Prof. Ehud Gazit, PhD, his team and collaborators. There, they toured labs and visited the BLAVATNIK CENTER for Drug Discovery, while also sharing research and learning new tech transfer strategies. Excellent opportunity for developing new synergies!

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Jul 25, 2023
Seminar: Metalloprotein chaperones: Regulating protein aggregation and metal ion dyshomeostasis in Alzheimer's disease. Cláudio M. Gomes (BioISI)

TWIN2PIPSA Coordinator Prof. Cláudio M. Gomes, PhD, gave a keynote lecture at the annual meeting of the Sociedade Portuguesa de Química (Portuguese Chemical Society) in Aveiro, Portugal. There, he shared his lab latest research on metalloprotein chaperones able to target Zn dyshomeostasis and protein aggregation in the context of Alzheimer's disease.

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2023
Paper: Interfacial Dynamics and Growth Modes of β2-Microglobulin Dimers.

PhD students Nuno F. B. Oliveira, Filipe E. P. Rodrigues and João N. M. Vitorino together with PIs Prof. Patrícia F. N. Faísca, PhD and Miguel Machuqueiro, PhD published their research on β2-Microglobulin dimer’s growth modes using computational modulations. Moreover, their paper was featured in the front cover of the Journal of Chemical Informaiton and Modeling. Congratulations!

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Jul 13, 2023
Meeting: 3rd Chem&Biochem Students Meeting (ULisboa)

Our PhD, MSc and BSc students participated in the 3rd Chem&Biochem Students Meeting at the Faculty of Sciences from ULisboa. There, they were able to showcase their projects in posters, flash and oral presentations, to more than 200 researchers. Also, PhD student António J. Figueira and MSc student Mariana Santos won Best Oral Presentation and Best Poster, respectively. Excellent job!

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Jul 06-12, 2023
Poster: Chaperone regulation of tau liquid-liquid phase separation. Guilherme G. Moreira (BioISI)

PhD student Guilherme G. Moreira from the Protein Misfolding and Amyloids in Biomedicine Lab (BioISI) presented his research on tau liquid-liquid phase separation at the 47th FEBS Congress 2023 and the associated 2023 FEBS Young Scientists’ Forum in Tours, France. He was awarded the BioFactors Poster Prize and was also a FEBS Letters Poster Prize Winner. Congratulations Guilherme! 

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IVentura Dissemination Event
Jun 22, 2023
Seminar: Blue biotechnology: from mimicry to application. Inês Ventura (MARE/BioISI)

PhD student Inês Ventura from the Bioadhesion & Biomimicry Lab (MARE) and the Protein Misfolding and Amyloids in Biomedicine Lab (BioISI), shared her work on sea urchin-inspired adhesive proteins at the Beer ISI PhD Seminars.

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May 31, 2023
Seminar: Mechanisms of protein dysfunction in rare metabolic disorders. Bárbara J. Henriques (BioISI)

Assistant Researcher Bárbara J. Henriques, PhD, part of the TWIN2PIPSA team of researchers based at Protein Misfolding and Amyloids in Biomedicine Lab (BioISI), shared her team's work on protein dysfunction in rare metabolic disorders in Copenhagen, Denmark, as part of her Scientific Exchange to UCPH. 

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BHenriques JRibeiro Exchange @ UCPH
May 30-31, 2023
Exchange: Perform computational analysis of disease variants (UCPH). Joana Ribeiro

PhD student Joana Ribeiro went on a Scientific Exchange to the University of Copenhagen, Denmark, learning new computational approaches to study disease variants of proteins associated to rare metabolic disorders from Prof. Dr. Kresten Lindorff-Larsen and his team.

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ULisboa Exchange @ UCPH
May 30-31, 2023
Exchange: Set-up experimental and computational methodologies for disease variants (UCPH). Bárbara J. Henriques

Assistant Researcher Bárbara J. Henriques, PhD, part of the TWIN2PIPSA team of researchers based at the Protein Misfolding and Amyloids in Biomedicine Lab (BioISI), went on a Scientific Exchange to the University of Copenhagen (UCPH), meeting there with Prof. Dr. Kresten Lindorff-Larsen and his team to share insights and plan new exciting collaborations.

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May 23-25, 2023
Poster: A sticky research: sea urchin bioinspired adhesive proteins. Inês Ventura (MARE)

PhD student Inês Ventura from the Bioadhesion & Biomimicry Lab (MARE) participated at The Global Synthetic Biology Conference (SynBioBeta 2023) in California, USA, where she shared her research on bioadhesives inspired on sea urchin's proteins with potential biotechnological applications.

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May 24, 2023
Seminar: A molecular simulation approach towards establishing the early phase of protein aggregation. Patrícia FN Faísca (BioISI)

Prof. Patrícia F. N. Faísca, PhD, part of the TWIN2PIPSA team of researchers and PI of the Biological Physics Lab (BioISI), shared her group's latest work at the Physics Seminar Coffee Talk series.

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May 18, 2023
Seminar: S100B chaperone multimers as novel regulators of protein aggregation and oligomerization in Alzheimer's Disease. António J. Figueira (BioISI)

PhD student António J. Figueira, from the Protein Misfolding and Amyloids in Biomedicine Lab (BioISI), shared his latest results regarding S100B suppressing activity against Aβ42 aggregation and neurotoxic oligomers at the Beer ISI PhD Seminars.

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May 11, 2023
Expert Seminar: Normal and abnormal huntingtin protein variants and their role in Huntington’s disease. Erich E. Wanker (MDC)

Prof. Erich E. Wanker, PhD, from the Max-Delbrück-Centrum für Molekulare Medizin (MDC) in Berlin shared his Lab's latest research on Huntington's disease-associated HTT protein, where they use quantitative multi-OMICs, protein-protein interaction studies and transgenic flies models.

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May 03, 2023
Event: Ciências Open Day 2023

T2P participated at the Ciências Open Day 2023 at the Faculty of Sciences of ULisboa. Here, we were able to showcase our research and its impact on protein science to early career researchers and high-school students looking to enter into STEM.

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Apr 27-28, 2023
Conference: Eurotau meetings 2023

TWIN2PIPSA participated in the Eurotau meetings 2023, with a talk by Prof. Cláudio M. Gomes, PhD, on the modulation of tau aggregation and condensation by chaperones, together with posters presented by PhD students Guilherme G. Moreira and Margarida Simões from his Lab.

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Apr 21, 2023
Digital Networking Event:
Predicting the early stages of protein aggregation: Dynamics and growth modes of beta-2-microglobulin dimers. João Vitorino (BioISI)

PhD student João Vitorino, from the Molecular Modeling & Simulation Lab at BioISI, presented their latest results on β-2-microglobulin aggregation, where they report a simple computational model to study β2M dimerization.

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Apr 18, 2023
Event: Jobshop Ciências 2023

TWIN2PIPSA was present at the Jobshop Ciências 2023, where we talked about our goals and research activities, as well as networking opportunities for scientific collaboration and industry partnerships.

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Apr 11, 2023
Expert Seminar: Multifunctional S100 proteins, from metallo-proteins to therapeutic targets. Guenter Fritz (University of Hohenheim)

Prof. Guenter Fritz, PhD, from the University of Hohenheim, Germany, shared his team's recent research on the world of S100 proteins through a TWIN2PIPSA Digital Networking Event.

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2023
Paper: S100B chaperone multimers suppress the formation of oligomers during Aβ42 aggregation.

S100B, a Ca2+-binding protein with holdase-like chaperone activity was evidenced to inhibit Aβ42 oligomerization and aggregation both as a dimer and tetramer, as shown in the paper published by PhD student António J. Figueira on Frontiers in Neuroscience.

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2023
Paper: Unraveling the Aquaporin-3 Inhibitory Effect of Rottlerin by Experimental and Computational Approaches.

A paper published by Inês Paccetti-Alves, MSc, on the International Journal of Molecular Sciences shows that Rottlerin (RoT) is able to inhibit human Aquaporin 3 (AQP3) activity, a relevant player in cancer and metastasis, unveiling RoT as an potential anticancer drug where AQP3 is highly expressed.

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Feb 03, 2023
Expert Seminar: Understanding the origins of loss of protein function using analyses of protein stability and conservation. Kresten Lindorff-Larsen (UCPH)

Prof. Kresten Lindorff-Larsen, PhD, representative of the University of Copenhagen (UCPH) in the TWIN2PIPSA consortium, showcased his team's work on merging computational methods with experimental data for studying protein dynamics and its relation to their structure and function at TWIN2PIPSA's kick-off meeting in Lisbon, Portugal.

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Feb 02, 2023
Expert Seminar: Peptide and Metabolite Assembly: Physiology, Pathology, and Nanotechnology. Ehud Gazit (TAU)

Prof. Ehud Gazit, PhD, representative of Tel Aviv University (TAU) in the TWIN2PIPSA consortium, shared his group's latest work on molecular structure and self-assembly at the nanoscale of peptides and metabolites at TWIN2PIPSA's kick-off meeting in Lisbon, Portugal.

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Feb 01, 2023
Expert Seminar: Thermodynamic and kinetic approaches for drug discovery to target protein misfolding and aggregation. Michele Vendruscolo (UCAM)

Prof. Michele Vendruscolo, PhD, representative of the University of Cambridge (UCAM) in the TWIN2PIPSA consortium, shared his team's latest research on protein misfolding and aggregation kinetics at TWIN2PIPSA's kick-off meeting in Lisbon, Portugal.

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Feb 01-03, 2023
TWIN2PIPSA Kick-off meeting

TWIN2PIPSA's kick-off meeting was held at Lisbon, Portugal. This 3-day meeting counted with the participation of the entire network of students, researchers and PIs involved in the project, where they shared their research, showcased available infrastructure and engaged in discussions. We also had three plenary lectures from partners Dr. Michele Vendruscolo (UCAM), Dr. Kresten Lindorff-Larsen (UCPH) and Dr. Ehud Gazit (TAU).

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TWIN2PIPSA Participants and Partners

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Faculdade de Ciências, Universidade de Lisboa
FCiências.ID - Associação para a Investigação e Desenvolvimento de Ciências
Campo Grande 1749-016 Lisboa Portugal

Funded by the EU (TWIN2PIPSA, GA 101079147). Views and opinions expressed are however those of the authors only and do not necessarily reflect those of the EU or European Research Executive Agency (REA). Neither the EU nor the granting authority can be held responsible for them.

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