ABOUT THE PROJECT
TWIN2PIPSA: Building a reference cluster for research in protein self-assembly at FCiências.ID/ULisboa
able to address major challenges in biomedicine and biotechnology.
Protein self-assembly and their underlying interactions are at the core of biological processes across organisms. Protein folding and misfolding, the formation of protein complexes from soluble multimers to insoluble amyloids, regulatory and signaling interactions between proteins and those involved in adhesion are some of the biological processes where PSA and PSIs play a critical role.
Impaired PPIs and dysfunctional PSA may lead to a loss-of-function phenotype, as in several metabolic disorders, or result in the formation of toxic aggregates, as in neurodegenerative diseases such as Alzheimer's or Huntington's. On the other hand, proteinaceous filaments may have a beneficial function for their host organism, as in the case of functional amyloids and adhesive proteins in echinoderms.
Addressing the complexity of PSA and PPIs calls for multidisciplinary approaches, combining experimental and computational techniques to capture and integrate phenomena across different scales - from molecules to cells and back.
Faculdade de Ciências, Universidade de Lisboa
FCiências.ID - Associação para a Investigação e Desenvolvimento de Ciências
Campo Grande 1749-016 Lisboa Portugal
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