EXCHANGES
Exchanges of TWIN2PIPSA members to partner institutions
TEAM TALKS & SEMINARS
Talks & seminars given by members of the TWIN2PIPSA team
CONFERENCES
• Best Oral Presentation Award to António J. Figueira at the 3rd Chem&Biochem Students Meeting at the Faculty of Sciences ULisboa
• Best Poster Presentation Award to Mariana Santos at the 3rd Chem&Biochem Students Meeting at the Faculty of Sciences ULisboa
• BioFactors Best Poster Award to Guilherme G. Moreira at the 22nd FEBS Young Scientists’ Forum
• Poster Prize of the Day from FEBS Letters to Guilherme G. Moreira at the 47th FEBS Congress
• Best Poster Award to Inês Ventura and Mariana Santos at the Instruct Biennial Structural Biology Conference 2024
• Best Oral Presentation in Biochemistry Award to Andreia Dias at the 4th Chem&Biochem Students Meeting at the Faculty of Sciences ULisboa
• Best Pitch Presentation in Biochemistry Award to Margarida Simões at the 4th Chem&Biochem Students Meeting at the Faculty of Sciences ULisboa
• Best Poster Presentation in Biochemistry Award to Pedro Peralta at the 4th Chem&Biochem Students Meeting at the Faculty of Sciences ULisboa
• Honorable Mention for Poster Presentation in Biochemistry to Ruy Domingos at the 4th Chem&Biochem Students Meeting at the Faculty of Sciences ULisboa
• IUPAB2024 Student and Early Career Researcher Poster Award to João Vitorino and João Sequeira at the IUPAB 2024 congress
• IUPAB Bursary award to João Sequeira to attend the International Union for Pure and Applied Biophysics 2024 Congress
• EBSA bursaries waiver awarder to João Sequeira to attend the European South Atlantic Biophysics Congress 2024
• Portuguese Biophysics Society Travel Grant to João Sequeira to attend the European South Atlantic Biophysics Congress 2024
• EBSA bursaries awarder to Marta Batista to attend the European South Atlantic Biophysics Congress 2024
• Portuguese Biophysics Society Travel Grant to Marta Batista to attend the European South Atlantic Biophysics Congress 2024
• FEBS Young Scientists’ Forum grant to António J. Figueira to attend the 48th FEBS Congress/23nd FEBS Young Scientists’ Forum
• EMBO|FEBS Travel Grant and Registration Fee Waiver to António J. Figueira to attend the EMBO|FEBS Susan Lindquist School on Proteostasis
• FEBS Youth Travel Grant to Margarida Simões to attend the FEBS Advanced Course on Protein Folding, Aggregation and Compartimentalization
• Portuguese Biophysics Society Travel Grant to Joana Ribeiro to attend the European Biophysical Societies' Association (EBSA) 2023 Congress
• FEBS Young Scientists’ Forum grant to Guilherme G. Moreira to attend the 47th FEBS Congress/22nd FEBS Young Scientists’ Forum
• Travel and Attendance Grant to Inês Ventura to attend the 2023 SynBioBeta conference
EVENTS
Training Schools
Introduce the ULisboa team to the advanced experimental and computational techniques used by UCPH researchers for the study of proteins and their interactions, and their relationships to function and disease.
Introduce the ULisboa team to the expertise of UCAM researchers and provide hands-on practice on pathological protein aggregation in protein conformational diseases and the development of therapeutic and diagnostic (small molecule and biologics) tools.
Introduce the ULisboa team to the conceptual and methodological expertise of TAU researchers underlying functional amyloids, peptide and metabolite assemblies, and protein-based biomaterials, with focus on their biotechnological potential and applicability.
PUBLICATIONS
• Simões MC, Cristóvão JS, Pardon E, Steyaert J, Fritz G, Gomes CM. Functional modulation of RAGE activation by multimeric S100B using single-domain antibodies. J Biol Chem. 2024;XX(X):XXX–XXX. https://doi.org/10.1016/j.jbc.2024.107983
• Habeck T, Zurmühl SS, Figueira AJ, Maciel EVS, Gomes CM, Lermyte F. Cross-Interactions of Aβ Peptides Implicated in Alzheimer's Disease Shape Amyloid Oligomer Structures and Aggregation. ACS Chem Neurosci. 2024;XX(X):XXX–XXX. https://doi.org/10.1021/acschemneuro.4c00492
• Oliveira NFB, Ladokhin AS, Machuqueiro M. Constant-pH MD simulations of the protonation-triggered conformational switching in diphtheria toxin translocation domain. Biophys J. 2024;XX(X):XXX–XXX. https://doi.org/10.1016/j.bpj.2024.08.023
• Freitas DP, Saavedra J, Cardoso I, Gomes CM. Biophysical Studies of Amyloid-Binding Fluorophores to Tau AD Core Fibrils Formed without Cofactors. Int J Mol Sci. 2024;25(18):9946. https://doi.org/10.3390/ijms25189946
• Carapeto AP, Marcuello C, Faísca PFN, Rodrigues MS. Morphological and Biophysical Study of S100A9 Protein Fibrils by Atomic Force Microscopy Imaging and Nanomechanical Analysis. Biomolecules. 2024;14(9):1091. https://doi.org/10.3390/biom14091091
• Murtinheira F, Farsetti E, Macedo L, Boasinha AS, Rodrigues MS, Fernandes A, Herrera F. A human microglial cell model of autosomal recessive spastic ataxia of Charlevoix-Saguenay. Biochim Biophys Acta Mol Basis Dis. 2024;1870(8):167452. https://doi.org/10.1016/j.bbadis.2024.167452
• Ferreira SGF, Sriramoju MK, Hsu SDH, Faísca PFN, Machuqueiro M. Is There a Functional Role for the Knotted Topology in Protein UCH-L1? J Chem Inf Model. 2024;64(17):6827–6837. https://doi.org/10.1021/acs.jcim.4c00880
• Mortelecque J, Zejneli O, Bégard S, Simões MC, ElHajjar L, Nguyen M, Cantrelle FX, Hanoulle X, Rain JC, Colin M, Gomes CM, Buée L, Landrieu I, Danis C, Dupré E. A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the Tau intrinsically disordered protein. J Bio Chem. 2024;300(4):107163. https://doi.org/10.1016/j.jbc.2024.107163
• Fortuna A, Suzano PMS, Machuqueiro M, Costa PJ. Influence of Iodine Merz-Singh-Kollman Radius on the Calculated Charges and Hydration Free Energies of Iodinated Molecule. J Comput Biophys Chem. 2024;23(4):481–491. https://doi.org/10.1142/S2737416523500722
• Fernandes PMP, Guedes RA, Victor BL, Salvador JAR, Guedes RC. Decoding the secrets: how conformational and structural regulators inhibit the human 20S proteasome. Front Chem. 2024;11:1322628. https://doi.org/10.3389/fchem.2023.1322628
• Coelho R, De Benedictis CA, Sauer AK, Figueira AJ, Faustino H, Grabrucker AM, Gomes CM. Secondary Modification of S100B Influences Anti Amyloid-β Aggregation Activity and Alzheimer’s Disease Pathology. Int J Mol Sci. 2024;25(3):1787. https://doi.org/10.3390/ijms25031787
(Pre-prints)
• Fortuna A, Costa PJ. Impact of the halogen PB radii in the estimation of protein-ligand binding energies using MM-PBSA calculations. ChemRxiv 2024. https://doi.org/10.26434/chemrxiv-2024-l32nf
• Diallo M, Pimenta C, Murtinheira F, Martins-Alves D, Pinto FR, da Costa AA, Letra-Vilela R, Martin V, Rodriguez C, Rodrigues MS, Herrera F. Asymmetric post-translational modifications regulate the nuclear translocation of STAT3 homodimers in response to leukemia inhibitory factor. Cell Oncol. 2023;XX:XXX–XXX. https://doi.org/10.1007/s13402-023-00911-9
• Fortuna A, Costa PJ. Assessment of Halogen Off-Center Point-Charge Models Using Explicit Solvent Simulations. J Chem Inf Model. 2023;63(23):7464–7475. https://doi.org/10.1021/acs.jcim.3c01561
• Neto V, Victor B, Galamba N. Cyclic Peptides as Aggregation Inhibitors for Sickle Cell Disease. J Med Chem. 2023;66(23):16062–16074. https://doi.org/10.1021/acs.jmedchem.3c01484
• Alves I, Batista MSP, Pimpão C, Victor BL, Soveral G. Unraveling the Aquaporin-3 Inhibitory Effect of Rottlerin by Experimental and Computational Approaches. Int J Mol Sci. 2023;24:6004. https://doi.org/10.3390/ijms24066004
• Ahonen T, Ng CP, Farinha B, Almeida B, Victor BL, Reynolds C, Kalso E, Yli-Kauhaluoma J, Greaves J, Moreira VM. Probing the Interactions of Thiazole Abietane Inhibitors with the Human Serine Hydrolases ABHD16A and ABHD12. ACS Med Chem Lett. 2023;14(10):1404–1410. https://doi.org/10.1021/acsmedchemlett.3c00313
• Ferreira-Peralta P, França B, Murtinheira F, Rodrigues MS, Herrera F. Is spastic ataxia 8 a protein misfolding disorder? Biochim Biophys Acta Mol Basis Dis. 2023;1870(1):166882. https://doi.org/10.1016/j.bbadis.2023.166882
• Figueira AJ, Saavedra J, Cardoso I, Gomes CM. S100B chaperone multimers suppress the formation of oligomers during Aβ42 aggregation. Front Neurosci. 2023;17:1162741. https://doi.org/10.3389/fnins.2023.1162741
• Gomes AMM, Costa PJ, Machuqueiro M. Recent advances on molecular dynamics-based techniques to address drug membrane permeability with atomistic detail. BBA Adv. 2023;4:100099. https://doi.org/10.1016/j.bbadva.2023.100099
• Sivickyte O, Costa PJ. Intrinsic bond strength index as a halogen bond interaction energy predictor. Phys Chem Chem Phys. 2023;25:17535. https://doi.or.pt/10.1039/d2cp04786a
(Pre-prints)
• Brás AR, Lopes A, Mendes N, Costa PJ, Ferreira A, Granja S, Silva AP, Tortosa F, Baltazar F, Gärtner F, Sousa MJ, Valente A, Preto A. Shifting KRAS hotspot mutations inhibition paradigm in colorectal cancer. bioRxiv 2023.08.09.552513. https://doi.org/10.1101/2023.08.09.552513
Interviews/News Publications
Mobirise