A multidisciplinary team of accomplished scientists from the Faculty of Sciences at the Universidade de Lisboa in Portugal, working together to understand functional and pathological protein self-assembly and identify the interactions that underlie the rational design of protein-based bio-materials and therapeutic antibodies.
Protein Misfolding and Amyloids in Biomedicine Lab
Dept. Chemistry and Biochemistry - BioISI/FCUL
Protein misfolding diseases and aggregation mechanisms. Amyloids. Neurodegenerative diseases. Liquid-liquid phase separation. Structural biochemistry. Biophysical spectroscopies.
Protein Misfolding and Amyloids in Biomedicine Lab
Dept. Chemistry and Biochemistry - BioISI/FCUL
Protein biochemistry. Protein misfolding in metabolic disorders. Structural biochemistry. Biophysical spectroscopies.
Cell Structures and Dynamics Lab
Dept. Chemistry and Biochemistry - BioISI/FCUL
Cell and molecular biology. Protein dynamics in cells. Fluorescence microscopy. Neurodegenerative disorders. Condensates.
Bioadhesion & Biomimicry Lab
Dept. Animal Biology - MARE/FCUL
Recombinant adhesive proteins. Sea urchin Omics. Marine adhesion. Biomimetic glues. Blue biotechnology & bioeconomy.
Computational Biophysics Lab
Dept. Chemistry and Biochemistry - BioISI/FCUL
Protein molecular dynamics. Modelling of lipid bilayers. pH effects in molecular simulations. Constant pH dynamics.
Structure-based Drug Discovery Lab
Dept. Chemistry and Biochemistry - BioISI/FCUL
Protein-ligand docking. Molecular dynamics simulations. Homology modelling of proteins. Drug design.
Computational Chemistry & Molecular Interactions Lab
Dept. Chemistry and Biochemistry - BioISI/FCUL
Protein-drug interactions. Theoretical reaction mechanisms. Quantum mechanics methods for molecular analysis.
Biological Physics Lab
Dept. Physics - BioISI/FCUL
Theory and simulations of protein folding and aggregation. Coarse-graining. Molecular dynamics. Monte Carlo methods. Knotted proteins.
Biological Physics Lab
Dept. Physics - BioISI/FCUL
Topological knots. Knotted proteins. Complex systems. Dynamical systems.
Atomic Force Microscopy and Related Techniques Lab
Dept. Physics - BioISI/FCUL
Single molecule experiments. Atomic Force Microscopy and Force-feedback microscopy. Force measurements in biology.
Atomic Force Microscopy and Related Techniques Lab
Dept. Physics - BioISI/FCUL
Atomic Force Microscopy and single molecule experiments. Protein Nanoscopy. Cell mechanics. Biomaterials.
Alice Melão, PhD
Carla Marques, PhD
Mafalda Pinto Basto, PhD
Bárbara Matos, PhD
Sara Costa, MSc
Mariana Santos, MSc
Andreia Dias, BSc
Constança Pimenta, BSc
Ana Ribeiro, BSc
Vasco Neto, MSc
Ruy Domingos, BSc
Joana Ribeiro, MSc
Guilherme Moreira, MSc
António Figueira, MSc
Margarida Simões, MSc
Daniela Freitas, MSc
Pedro Peralta, MSc
Carina Coelho, MEd
André Costa, MSc
Nuno Oliveira, MSc
João Sequeira, MSc
João Vitorino, MSc
Inês Ventura, MSc
Fernanda Murtinheira, MSc
João Especial, MSc
Andreia Fortuna, MSc
Sara Ferreira, MSc
Filipe Rodrigues, MSc
Tel Aviv University (TAU) is represented in this consortium by Ehud Gazit and his group. These researchers bring expertise in protein- and metabolite-based materials with multiple applications in biotechnology, including biosensors, nanotubes and composite materials. The consortium will benefit from TAU's exceptional research infrastructure for protein interaction analysis, nanoscale characterization, and application development.
The Shmunis School of Biomedicine and Cancer Research
Molecular self-assembly of biological, bio-inspired and other organic building blocks. Protein-based materials inspired in amyloids. Nano assemblies for ultra-sensitive peptide-based biosensor applications.
Senior Researchers
● Sharon Gilead, PhD
● Dana Laor, PhD
Recognized Researchers
● Yu Chen, PhD
● Om Shanker Tiwari, PhD
First Stage Researchers (PhD students)
● Gal Finkelstein-Zuta
UCPH is represented by Kresten Lindorff-Larsen and his group, who excels in biomolecular sciences, notably in the quantitative analysis of proteins and other biomolecules through advanced computational approaches. This group brings expertise on the integration of computational methods with experimental data for studying protein folding mechanisms and protein-protein interactions.
Linderstrøm-Lang Centre for Protein Science
Protein dynamics and their relationship to protein structure and function. Integration of molecular simulations with structural biology. Combination of high-throughput experiments with computational biophysics and data science to understand of variant effects in disease.
Senior Researchers
● Kristoffer Enøe Johansson, PhD
● Giulio Tesei, PhD
Recognized Researchers
● Matteo Cagiada, PhD
● Johanna Tieman, PhD
● Francesco Pesce, PhD
First Stage Researchers (PhD students)
● Thea Klarsø Schulze
● Lasse Blaabjerg
● Nicolas Jonsson
UCAM is represented in this consortium by Michele Vendruscolo and his group. It is an internationally recognized world leading institution and research group on protein misfolding diseases that will contribute with expertise on the biology and biomedical applications of pathological protein aggregation. UCAM provides know-how on quantitation of protein oligomers, microfluidics, computational approaches, advanced imaging techniques and drug design.
Centre for Misfolding Diseases
Molecular origins of neurodegenerative disorders. Protein folding and aggregation in neurodegenerative disease. AI for protein (mis)folding. Drug discovery. AFM. Microfluidics. Single molecule analyses. Antibody design.
Senior Researchers
● Sophie Jackson, PhD
● Johnny Habchi, PhD
● Pietro Sormanni, PhD
● Steven Lee, PhD
● Zenon Toprakcioglu, PhD
● Rosana C. Guevara, PhD
● Gonçalo Bernardes, PhD
● James Tomkins, PhD
Recognized Researchers
● Faidon Brotzakis, PhD
First Stage Researchers (PhD students)
● Alyssa Miller
● Alicia González Díaz
● Alexander Röntgen
● Vaidehi Chowdhury
● Jonathan Breiter
● Owen Morris
Faculdade de Ciências, Universidade de Lisboa
FCiências.ID - Associação para a Investigação e Desenvolvimento de Ciências
Campo Grande 1749-016 Lisboa Portugal
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