TWIN2PIPSA ULisboa team highlights Protein Folding research at the 5th Ciências Research & Innovation Day

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24 October, 2023

The TWIN2PIPSA project was present at the Ciências Research & Innovation Day, an event that aims to display the scientific excellence of the Faculdade de Ciências da Universidade de Lisboa. The research and academic community of Ciências ULisboa had the opportunity to know more about TWIN2PIPSA consortium and its scientific developmental goals through a talk given by the project coordinator, Professor Cláudio Gomes. In addition, the most recent findings of the TWIN2PIPSA ULisboa team were presented by the PhD students Nuno Oliveira, from the Computational Biophysics Lab, Margarida Simões, from the Protein Misfolding and Amyloids in Biomedicine Lab, Fernanda Murtinheira, from the Cell Structure and Dynamics Lab, and Inês Ventura, from the Bioadhesion and Biomimicry Research Lab.

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Nuno Oliveira et al., Remodeling Lewis base anti-cancer drugs to selectively target acidic tumors

Using molecular docking simulations, the team explored the antitumor potential of modified drugs and their ability to penetrate the acidic tumor environment.

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Margarida Simões et al., Nanobodies as protein-based tools to modulate Tau aggregation in Alzheimer’s disease

The team explored the capacity of single-domain antibodies (nanobodies) to target S100B, a potentially pathogenic protein that can promote inflammation and prevent protein aggregates in the aging brain.

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Fernanda Murtinheira et al., Biochemical and biophysical alterations in glial cell models of the Autosomal Recessive Ataxia of Charlevoix-Saguenay (ARSACS)

Using in vitro cellular models of structural cells from the central nervous system (known as glial cells), the team explored the role and contribution of Sacsin protein for the development of ARSACS and potentially of other human ataxia-related diseases.

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Inês Ventura et al., A STICKY RESEARCH - Bioinspired adhesive proteins from
marine organisms

Inspired by the proprieties of the specialized bioadhesives produced by sea urchins, the team aims to design biomimetic adhesive compounds that can be applied to different technological fields, including biomedicine.

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Credits: Ciências ULisboa
https://doi.org/10.5281/zenodo.10059097

The Ciências Research & Innovation Day is an event that takes place within the Ciências Research and Innovation Week 2023, which is dedicated to uncover the various innovation branches being developed at Ciências ULisboa, focusing on the three main current societal challenges - the rise of artificial intelligence, climate action and energy transition. Taking place from 23 to 27 of October, several events will allow the Ciências ULisboa community to discover the diversity of scientific projects developed at the Faculty, but also to know the members of FCiências.ID, the Association for Research and Development of Sciences, thereby providing opportunities for networking and to pave the way for future collaborations. 

"This event is an opportunity to publicize and celebrate the quality of research and innovation developed at Ciências ULisboa, the ideal occasion for sharing knowledge, establishing collaborations and reinforcing the sense of identity of this century-old institution, a national and international reference," the subdiretor of the faculty for the research area Margarida Santos-Reis underscored in a press release.

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Faculdade de Ciências, Universidade de Lisboa
FCiências.ID - Associação para a Investigação e Desenvolvimento de Ciências
Campo Grande 1749-016 Lisboa Portugal

Funded by the EU (TWIN2PIPSA, GA 101079147). Views and opinions expressed are however those of the authors only and do not necessarily reflect those of the EU or European Research Executive Agency (REA). Neither the EU nor the granting authority can be held responsible for them.

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