TWIN2PIPSA

Twinning for Excellence in Biophysics of
Protein Interactions & Self-Assembly

An EU-funded project coordinated by FC.ID/ULisboa
Faculdade de Ciências Universidade de Lisboa

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Meet the team

A group of 11 scientists from Ciências/ULisboa together with our partners from Tel Aviv University (TAU), University of Copenhagen (UCPH), and the University of Cambridge (UCAM), make up the team of experts that collaborate under the TWIN2PIPSA project.

Consortium >
3D_Molecule
Twinning for Excellence in Protein Science
Visit of High-School Students to TWIN2PISPA Research Labs
Digital Network Event: Integrating Molecular Dynamics Simulations with Small-angle X-ray Scattering to Characterize Multidomain Proteins and Their Assemblies
3D-BioInfo-PT Intermediate Workshop and Annual Meeting
Seminar: Why are halophilic proteins rich in acidic amino acids?
Interview: Cláudio Gomes in 90 Segundos Ciência (in Portuguese)
Bárbara Henriques at CIÊNCIAS Research & Innovation Day
European Researchers' Night - Lisboa
Workshop: 3D-BioInfo-PT Introductory Workshop
Workshop: Bioimaging and Spectroscopy for Protein Interactions Analysis 
Paper: Morphological and Biophysical Study of S100A9 Protein Fibrils by Atomic Force Microscopy Imaging and Nanomechanical Analysis
Paper: A human microglial cell model of autosomal recessive spastic ataxia of Charlevoix-Saguenay
Paper: Is There a Functional Role for the Knotted Topology in Protein UCH-L1?
Conference: Joint IEC & IHM 2024
Seminar: Use of tau-specific single domain antibodies to inhibit tau aggregation nucleation and seeding in neurodegenerative diseases
Conference: 4th Chem & Biochem Students Meeting
Conference: 21st IUPAB Congress 2024
Universidade de Lisboa/Caixa Geral de Depósitos Prizes
Seminar: Protein interactions gone awry in neurodegenerative diseases
Congress: ICNI-III Belgrade 2024
Interview: Bárbara Henriques in 90 Segundos Ciência (in Portuguese)
Conference: European South Atlantic Biophysics Congress 2024
Outreach Event: 3 Minutes Thesis ULisboa
Conference: Instruct Biennial Structural Biology Conference 2024
Workshop: Excellent Frontier Research: Strategic Perspectives for ERC Successful Funding
MOSBRI Basic-Level School
Ciências Open Day 2024
Seminar: Self-assembly of Therapeutic Peptides
Scientific Exchange to University of Copenhagen
Outreach: TWIN2PIPSA goes to school
Seminar: methods to capture the pH effects in drug binding to proteins and membranes
Meeting: Annual International (Bio)Medical Students Meeting
3D-BioInfo-PT Advanced Workshop
Jobshop Ciências 2024
Visit of Students from The Netherlands
Webinar for Middle- and High-school Students on 'Marine Molecules in Our Daily Lives'
Meeting: 20th International Symposium of the Portuguese Society of Metabolic Disorders
 Digital Networking Event: Piezoelectric Biomaterials Toward Energy Harvesting
 Congress: AD/PD 2024
 Event: Bridging opportunities and forging partnerships with biotech/industrial stakeholders 
Seminar: Physics of Knotter Proteins
Paper: Secondary Modification of S100B Influences Anti Amyloid-β Aggregation Activity and Alzheimer’s Disease Pathology
International Day of Women and Girls in Science 
Workshop: How to design a CRISPR/Cas9 system to study protein-protein interactions in live cells 
Webinar for Middle- and High-school Students on the Innovative Potential of Materials Inspired in Marine Organisms 
Ciências ULisboa | Tec Labs Internal Competition for Science Innovation Projects 
Science Management Staff Exchange to University of Cambridge
Training School 2: From pathological protein aggregation to drug discovery
Visit of High-School Students to Ciências ULisboa
Expert Seminar: Targeting Ataxin-3 aggregation: Clues for Machado-Joseph's disease therapy
On-Site Training: Computational strategies for analysing protein structures 
Expert Seminar: Bacteria to the rescue: engineering microorganisms to function as an early-stage living drug discovery platform for protein misfolding diseases
Workshop: Navigating EU Research & Innovation Funding: Leveraging Current Experiences for Future Opportunities
Interview: TWIN2PIPSA project in Antena 2 Ciência (in Portuguese)
Training School 1: Integrating experimental and computational approaches in protein self-assembly
Event: Ciências Research and Innovation Day 2023
Digital Networking Event: AlphaFold Prediction of Structural Ensembles of Disordered Proteins. Faidon Brotzakis (UCAM)
Scientific Exchanges to University of Cambridge
Seminar: The regulation of Aβ42 oligomerization and aggregation by multimers of the S100B chaperone. António J. Figueira (BioISI)
Event: European Researchers' Night - Lisboa
PhD Review: New underwater sea urchin inspired bioadhesives. Inês Ventura (BioISI/MARE).
Expert Seminar: Designer biomolecular condensates formed by peptide liquid-liquid phase separation. Ayala Lampel (TAU).
Expert Seminar: Interactions and conformational switching of Bcl-2 protein family of apoptotic regulators. Alexey Ladokhin (KU)
Conference: 5th International Symposium on Pathomechanisms of Amyloid Diseases
Seminar: Anti-S100B nanobodies as modulators of Tau aggregation. Margarida Simões (BioISI).
Congress: EBSA 2023
Seminar: Monitoring protein dynamics in living cells in the context of neurodegenerative disorders. Federico Herrera (BioISI)
Seminar: Acyl-CoA metabolites as a regulators of enzyme function through protein acylation. Bárbara J. Henriques (BioISI)
Seminar: Sea urchin inspired adhesives for biotechnological and biomedical applications. Romana Santos (MARE)
Seminar: Novel chaperones counteracting protein aggregation in neurodegeneration. Cláudio M. Gomes (BioISI)
Scientific Exchanges to Tel Aviv University. Cláudio M. Gomes, Romana Santos, M Bárbara J. Henriques, Federico Herrera
Seminar: Metalloprotein chaperones: Regulating protein aggregation and metal ion dyshomeostasis in Alzheimer's disease. Cláudio M. Gomes (BioISI)
Paper: Interfacial Dynamics and Growth Modes of β2-Microglobulin Dimers.
Meeting: 3rd Chem&Biochem Students Meeting (ULisboa)
Poster: Chaperone regulation of tau liquid-liquid phase separation. Guilherme G. Moreira (BioISI)
Seminar: Blue biotechnology: from mimicry to application. Inês Ventura (MARE/BioISI)
Seminar: Mechanisms of protein dysfunction in rare metabolic disorders. Bárbara J. Henriques (BioISI)
Exchange: Perform computational analysis of disease variants (UCPH). Joana Ribeiro
Exchange: Set-up experimental and computational methodologies for disease variants (UCPH). Bárbara J. Henriques
Poster: A sticky research: sea urchin bioinspired adhesive proteins. Inês Ventura (MARE)
Seminar: A molecular simulation approach towards establishing the early phase of protein aggregation. Patrícia FN Faísca (BioISI)
Seminar: S100B chaperone multimers as novel regulators of protein aggregation and oligomerization in Alzheimer's Disease. António J. Figueira (BioISI)
Expert Seminar: Normal and abnormal huntingtin protein variants and their role in Huntington’s disease. Erich E. Wanker (MDC)
Event: Ciências Open Day 2023
Conference: Eurotau meetings 2023
Digital Networking Event:
Predicting the early stages of protein aggregation: Dynamics and growth modes of beta-2-microglobulin dimers. João Vitorino (BioISI)
Event: Jobshop Ciências 2023
Expert Seminar: Multifunctional S100 proteins, from metallo-proteins to therapeutic targets. Guenter Fritz (University of Hohenheim)
Paper: S100B chaperone multimers suppress the formation of oligomers during Aβ42 aggregation.
Paper: Unraveling the Aquaporin-3 Inhibitory Effect of Rottlerin by Experimental and Computational Approaches.
Expert Seminar: Understanding the origins of loss of protein function using analyses of protein stability and conservation. Kresten Lindorff-Larsen (UCPH)
Expert Seminar: Peptide and Metabolite Assembly: Physiology, Pathology, and Nanotechnology. Ehud Gazit (TAU)
Expert Seminar: Thermodynamic and kinetic approaches for drug discovery to target protein misfolding and aggregation. Michele Vendruscolo (UCAM)
TWIN2PIPSA Kick-off meeting

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